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訂購信息
上海拜力生物科技公司
Tel:400-968-7988    021-33779008
Quidel KLOTHO Antibody (KL1)
品牌:Quidel
貨號:21-9159
規(guī)格:100 μg
貨期:電詢
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商品詳情 參考文獻 相關(guān)資料

產(chǎn)品介紹

名稱

Quidel KLOTHO Antibody (KL1)

貨號

 21-9159

規(guī)格

 100 μg

 同種型

 IgG1κ

蛋白質(zhì)濃度

 Refer to CoA

純度

Varies (refer to CoA)

緩沖液

Phosphate Buffered Solution (PBS), with 0.1% sodium azide

儲存

2°C to 8°C* (≤ 30 days)

*For long-term storage (> 30 days), aliquot and store at ≤ –20°C. Avoid repeated freeze-thaw.

物種反應(yīng)

No cross reactivity with non-human specimens is observed

使用說明

For Research Use Only. Not for use in diagnostic procedures. 

產(chǎn)品描述

Klotho, named after one of the Fates in Greek mythology, is a type-I transmembrane protein that is associated with many functions. A novel ?-glucuronidase, Klotho has been associated with phosphate regulation, organ protection, and aging, among others. Though a single gene, it has 3 major isoforms: the transmembrane form, a shed soluble form, and a truncated soluble form. The extracellular portion of the protein consists of two glycosyl hydrolase domains referred to as KL1 and KL2. Upon cleavage at the base of the extracellular domain the protein becomes the shed soluble form, and is an active form that functions as a hormone.

背景

 Importantly, Klotho is a receptor and a co-receptor of the phosphate regulation protein FGF-23. While Klotho/ FGF-23 homeostasis has primarily been focused on phosphate and vitamin D regulation, continuing research is associating Klotho and FGF-23 with functionality that impacts the heart, bones, blood vessels, and parathyroid gland

應(yīng)用

Because specific techniques differ from lab to lab, the provided information should be used as a guideline only. The antibody was developed and validated by ELISA and Western Blot (WB). For additional WB information

特異性

The specificity of the monoclonal antibody was established via epitope mapping and a series of immunoassays. The antibody binds the KL1 domain of the Klotho protein. Quidel KLOTHO Antibody (KL1)

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