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PR-619,DeubiquitinylatingEnzyme(DUB)Inhibitor

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PR-619,DeubiquitinylatingEnzyme(DUB)Inhibitor

品牌：Xcessbio

貨號(hào)：M60199-2s

規(guī)格：2 mg solid

貨期：

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PR-619,DeubiquitinylatingEnzyme(DUB)Inhibitor

商品詳情參考文獻(xiàn) 相關(guān)資料

Product Information

Molecular Weight:	223.28
Formula:	C₇H₅N₅S₂
Purity:	≥98%
CAS#:	2645-32-1
Solubility:	DMSO up to 100 mM
Chemical Name:	3,5-dithiocyanatopyridine-2,6-diamine
Storage:	Powder: 4^oC 1 year. DMSO: 4^oC 3 month; -20^oC 1 year.

Biological Activity:

PR-619 is a cell-permeable, non-selective, reversible broad-range inhibitor of the deubiquitinylating enzymes (DUBs) with IC₅₀ of 1-20 μM. PR-619 is shown to increase overall protein polyubiquitination in HEK293T cells in a dose- and time-dependent manner (20 to 150 μM, 0.5 to 20 h) without direct impairment of proteasomal proteolysis. PR-619 treatment results in upregulation of both K⁴⁸ - and K⁶³-linked polyUb chains. It induces HCT116 cell death with EC₅₀ ~6.3 μM.

How to Use:

In vitro: PR-619 was used at 10-50 μM final concentration in various in vitro assays.
In vivo: n/a

Reference:

1. Altun M, et al. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (2011) Chem Biol. 18(11):1401-12.

Products are for research use only. Not for human use.

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