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Anti-FBXL21 Antibody

品牌：Antibodies

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規(guī)格：100μl

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Anti-FBXL21 Antibody

商品詳情參考文獻相關資料

Overview

Name:	Anti-FBXL21 Antibody See all FBXL21 primary antibodies
Description:	Rabbit polyclonal antibody to FBXL21
Applications:	ELISA, WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Rabbit polyclonal FBXL21 (1) antibody was raised against a recombinated human FBXL21 protein 1-138aa (BC106753).
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity purified
Concentration:	1.0mg / ml
Formulation:	PBS, pH 7.4 with 0.02% Sodium Azide
Storage:	This product is stable for several weeks at 4?C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20?C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Target

Function:	Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities.
Tissue Specificity:	Expressed in the hypothalamus, especially in the suprachiasmatic nucleus (SCN). Expression is driven by the core-clock. There is a pronounced diurnal and circadian expression rhythms rising rapidly at the start of the day and declining at the onset of the night.
Cellular Location:	Cytoplasm > Cytosol. Nucleus. Mainly localizes in the cytosol. Present at low level in the nucleus.
Database Links:	Entrez Gene: 26223?Human Entrez Gene: 213311?Mouse Omim: 609087?Human SwissProt: Q9UKT6?Human SwissProt: Q8BFZ4?Mouse Unigene: 591275?Human Unigene: 233904?Mouse
Synonyms:	F box and leucine rich repeat protein 21 Antibody F box and leucine rich repeat protein 3 pseudogene Antibody F box and leucine rich repeat protein 3B Antibody F box protein Fbl3b Antibody F box/LRR repeat protein 21 Antibody F box/LRR repeat protein 3B Antibody F-box and leucine-rich repeat protein 21 Antibody F-box and leucine-rich repeat protein 3B Antibody F-box/LRR-repeat protein 21 Antibody F-box/LRR-repeat protein 3B Antibody Fbl 21 Antibody FBL 3 Antibody FBL 3B Antibody Fbl21 Antibody FBL3 Antibody FBL3B Antibody FBXL 21 Antibody FBXL 3B Antibody FBXL 3P Antibody FBXL21 Antibody FBXL3B Antibody FBXL3P Antibody FXL21_HUMAN Antibody MGC120237 Antibody
Information:	Target information shown above is from the UniProt Consortium.