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Anti-FANCL Antibody

品牌：Antibodies

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規(guī)格：100μg

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Anti-FANCL Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-FANCL Antibody See all FANCL primary antibodies
Description:	Goat polyclonal antibody to FANCL.
Applications:	ELISA, WB
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human FANCL (internal region).
Sequence:	C-QNLKDVLEIDFP
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.
Involvement in Disease:	Fanconi anemia complementation group L: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
Post-Translational Modification:	The RING-type zinc finger domain is monoubiquitinated in the presence of UBE2T and UBE2W.
Cellular Location:	Cytoplasm. Nucleus.
Database Links:	Entrez Gene: 55120?Human Omim: 608111?Human SwissProt: Q9NW38?Human Unigene: 631890?Human
Synonyms:	E3 ubiquitin-protein ligase FANCL Antibody FAAP43 Antibody FANCL Antibody FANCL_HUMAN Antibody Fanconi anemia complementation group L Antibody Fanconi anemia group L protein Antibody Fanconi anemia-associated polypeptide of 43 kDa Antibody FLJ10335 Antibody PHD finger protein 9 Antibody PHF9 Antibody POG Antibody Ubiquitin ligase protein FANCL Antibody
Information:	Target information shown above is from the UniProt Consortium.