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Anti-FANCA (phospho-S1149) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-FANCA (phospho-S1149) Antibody

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Overview

Name:	Anti-FANCA (phospho-S1149) Antibody See all FANCA primary antibodies
Description:	Rabbit polyclonal antibody to FANCA (phospho-S1149)
Specificity:	p-FANCA (S1149) pAb detects endogenous levels of FANCA protein only when phosphorylated at Ser1149.
Applications:	WB, IHC, ICC, IP
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic phosphopeptide derived from human FANCA around the phosphorylation site of Serine 1149.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 163 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
Involvement in Disease:	Fanconi anemia, complementation group A: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
Post-Translational Modification:	Phosphorylation is required for the formation of the nuclear complex. Not phosphorylated in cells derived from groups A, B, C, E, F, G, and H.
Cellular Location:	Nucleus. Cytoplasm. The major form is nuclear. The minor form is cytoplasmic.
Database Links:	Entrez Gene: 2175?Human Entrez Gene: 14087?Mouse Omim: 607139?Human SwissProt: O15360?Human SwissProt: Q9JL70?Mouse Unigene: 290154?Human
Synonyms:	FA Antibody FA 1 Antibody FA H Antibody FA1 Antibody FAA Antibody FACA Antibody FAH Antibody FANCA Antibody FANCA_HUMAN Antibody FANCH Antibody Fanconi anemia complementation group A Antibody Fanconi anemia complementation group H Antibody Fanconi anemia group A protein Antibody Fanconi anemia type 1 Antibody MGC75158 Antibody Protein FACA Antibody
Information:	Target information shown above is from the UniProt Consortium.