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產(chǎn)品介紹
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品名
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Quidel Monoclonal Antibody to Human iC3b (neoantigen)
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貨號
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A209
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規(guī)格
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100 μL
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同種型
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IgG2bk
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蛋白質(zhì)濃度
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> 1.0 mg/mL
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純度
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> 95% by SDS PAGE
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緩沖液
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Borate Buffered Saline (pH 8.4 ± 0.2)
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儲存
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Short term (30 days) 4?C
Long term at or below –20?C
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使用說明
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For Research Use Only. Not for use in Diagnostic Procedures
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產(chǎn)品描述
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A murine monoclonal antibody to a neo-epitope expressed on iC3b.
This monoclonal antibody was raised against purified human iC3b. It is specific for a neo-antigen on iC3b.
Quidel's iC3b monoclonal antibody has been used in a variety of experimental techniques including EIA, Western Blot, Flow Cytometry, RIA, Hemagglutination and Immunohistochemistry.
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背景
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Under normal conditions, activation of either of the complement pathwaysleadsto the formation of C3 convertase enzymes which cleave C3 into two fragments C3a, an anaphylatoxin, and C3b.The C3b fragment has many biologic functions1 including promotion of phagocytosis and participation as a structural component in both the C3 and C5 convertase enzymes.These processes are under stringent control in vivo.One control mechanism involves a two-site cleavage of C3b by Factor I with the cooperation of Factor H or CR1 as cofactors.When cleaved in this way the biologic functions of C3b are lost.The resulting protein is termed iC3b.This fragment, in turn,has a host of new biologic activities.
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應(yīng)用
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Please contact Quidel Specialty Products Technical Services for application specific information.
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參考資料
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Tamerius, J.D., Pangburn, M., et al. Detection of a neoantigen on human iC3b and C3d by monoclonal Antibody, J. Immunol. 135:2015, 1985.
Rogers, J., Cooper, N., et al. Complement Activation by ?-amyloid in Alzheimer disease, PNAS 89:10016-10020, 1992.
Gemmell, C. A flow cytometric immunoassay to quantify adsorption of complement activation products on artificial surfaces, J Biomed Mater Res 37, 474-480, 1997.
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